Your bundle is guaranteed to be smaller, and will also evaluate faster because there's less indirection (more information on that — The cost of small modules). The trade-off is that this behaviour relies on ES2015 module semantics, and it means that some of webpack's advanced features are much harder...

Also, there is pyfuse3 project which seems to be official. Finally, there is another project python-llfuse which is recommended by Nikratio one of the libfuse developers. So, as there is a good-old-official version that has a maintainer now, I tried to start with python-fuse on FreeBSD.